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Case Reports
. 1991 Mar;52(3):105-7.

Clozapine-induced neuroleptic malignant syndrome

K DasGupta  1 , A Young
Affiliations
  • PMID: 2005072
Case Reports

Clozapine-induced neuroleptic malignant syndrome

K DasGupta et al. J Clin Psychiatry. 1991 Mar.

Abstract

Neuroleptic malignant syndrome (NMS), a rare but serious side effect of psychotropic drugs, is usually attributed to blockade of striatal and hypothalamic dopaminergic tracts. Clozapine is an atypical antipsychotic that has minimal extrapyramidal effects and might not be expected to cause NMS. The authors report the development of NMS in a 30-year-old white man after three 25-mg clozapine doses. To their knowledge, this is the first case of NMS linked with clozapine in which concurrent psychotropic medications cannot be implicated.

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Comment in

  • NMS and lethal catatonia.
    Weller M. Weller M. J Clin Psychiatry. 1992 Aug;53(8):294-5. J Clin Psychiatry. 1992. PMID: 1500409 No abstract available.

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