Naturally occurring phytochemicals for the prevention of Alzheimer's disease
- PMID: 20050972
- DOI: 10.1111/j.1471-4159.2009.06562.x
Naturally occurring phytochemicals for the prevention of Alzheimer's disease
Abstract
Alzheimer's disease (AD) is an age-related neurodegenerative disease increasingly recognized as one of the most important medical problems affecting the elderly. Although a number of drugs, including several cholinesterase inhibitors and an NMDA receptor antagonist, have been approved for use, they have been shown to produce diverse side effects and yield relatively modest benefits. To overcome these limitations of current therapeutics for AD, extensive research and development are underway to identify drugs that are effective and free of undesirable side effects. Certain naturally occurring dietary polyphenolic phytochemicals have received considerable recent attention as alternative candidates for AD therapy. In particular, curcumin, resveratrol, and green tea catechins have been suggested to have the potential to prevent AD because of their anti-amyloidogenic, anti-oxidative, and anti-inflammatory properties. These polyphenolic phytochemicals also activate adaptive cellular stress responses, called 'neurohormesis', and suppress disease processes. In this commentary, we describe the amyloid-beta-induced pathogenesis of AD, and summarize the intracellular and molecular targets of selected dietary phytochemicals that might slow the progression of AD.
Similar articles
-
Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents.Expert Rev Neurother. 2010 May;10(5):729-45. doi: 10.1586/ern.10.42. Expert Rev Neurother. 2010. PMID: 20420493 Review.
-
Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical.Food Funct. 2012 Dec;3(12):1242-50. doi: 10.1039/c2fo30075c. Food Funct. 2012. PMID: 22929970 Review.
-
The protective role of plant biophenols in mechanisms of Alzheimer's disease.J Nutr Biochem. 2017 Sep;47:1-20. doi: 10.1016/j.jnutbio.2017.02.016. Epub 2017 Mar 3. J Nutr Biochem. 2017. PMID: 28301805 Review.
-
Pleiotropic protective effects of phytochemicals in Alzheimer's disease.Oxid Med Cell Longev. 2012;2012:386527. doi: 10.1155/2012/386527. Epub 2012 May 28. Oxid Med Cell Longev. 2012. PMID: 22690271 Free PMC article. Review.
-
Antioxidant strategies for Alzheimer's disease.Proc Nutr Soc. 2002 May;61(2):191-202. doi: 10.1079/PNS2002146. Proc Nutr Soc. 2002. PMID: 12133201 Review.
Cited by
-
Cocoa powder triggers neuroprotective and preventive effects in a human Alzheimer's disease model by modulating BDNF signaling pathway.J Cell Biochem. 2013 Oct;114(10):2209-20. doi: 10.1002/jcb.24548. J Cell Biochem. 2013. PMID: 23554028 Free PMC article.
-
The Effect of a Tribulus-Based Formulation in Alleviating Cholinergic System Impairment and Scopolamine-Induced Memory Loss in Zebrafish (Danio rerio): Insights from Molecular Docking and In Vitro/In Vivo Approaches.Pharmaceuticals (Basel). 2024 Feb 2;17(2):200. doi: 10.3390/ph17020200. Pharmaceuticals (Basel). 2024. PMID: 38399415 Free PMC article.
-
A Review on Coordination Properties of Al(III) and Fe(III) toward Natural Antioxidant Molecules: Experimental and Theoretical Insights.Molecules. 2021 Apr 29;26(9):2603. doi: 10.3390/molecules26092603. Molecules. 2021. PMID: 33946938 Free PMC article. Review.
-
Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species.Dalton Trans. 2012 Jun 7;41(21):6558-66. doi: 10.1039/c2dt12207c. Epub 2012 Mar 22. Dalton Trans. 2012. PMID: 22437427 Free PMC article.
-
Resveratrol protects rats from Aβ-induced neurotoxicity by the reduction of iNOS expression and lipid peroxidation.PLoS One. 2011;6(12):e29102. doi: 10.1371/journal.pone.0029102. Epub 2011 Dec 29. PLoS One. 2011. PMID: 22220203 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical