doi: 10.1093/jmcb/mjp054.
Epub 2010 Jan 5.
Janus kinase 2: an epigenetic 'writer' that activates leukemogenic genes
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- PMID: 20051435
- DOI: 10.1093/jmcb/mjp054
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Janus kinase 2: an epigenetic 'writer' that activates leukemogenic genes
J Mol Cell Biol.
2010 Oct.
Abstract
Activation of Janus kinase 2 (JAK2) plays a critical role in normal hematopoiesis and leukemogenesis. Dawson et al. (2009; JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, 819-822) report that JAK2 performs this function by displacing the heterochromatin protein HP1α from chromatin through phosphorylation of histone H3.
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