Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Oct;2(5):231-3.
doi: 10.1093/jmcb/mjp054. Epub 2010 Jan 5.

Janus kinase 2: an epigenetic 'writer' that activates leukemogenic genes

Jin He  1 , Yi Zhang
Affiliations

Janus kinase 2: an epigenetic 'writer' that activates leukemogenic genes

Jin He et al. J Mol Cell Biol. 2010 Oct.

Abstract

Activation of Janus kinase 2 (JAK2) plays a critical role in normal hematopoiesis and leukemogenesis. Dawson et al. (2009; JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, 819-822) report that JAK2 performs this function by displacing the heterochromatin protein HP1α from chromatin through phosphorylation of histone H3.

PubMed Disclaimer