Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009:2009:934698.
doi: 10.1155/2009/934698. Epub 2009 Dec 13.

Cost-effectiveness of universal prophylaxis in pregnancy with prior group B streptococci colonization

Mark A Turrentine  1 , Mildred M Ramirez, Joan M Mastrobattista
Affiliations

Cost-effectiveness of universal prophylaxis in pregnancy with prior group B streptococci colonization

Mark A Turrentine et al. Infect Dis Obstet Gynecol. 2009.

Abstract

Objective: To estimate the costs and outcomes of rescreening for group B streptococci (GBS) compared to universal treatment of term women with history of GBS colonization in a previous pregnancy.

Study design: A decision analysis model was used to compare costs and outcomes. Total cost included the costs of screening, intrapartum antibiotic prophylaxis (IAP), treatment for maternal anaphylaxis and death, evaluation of well infants whose mothers received IAP, and total costs for treatment of term neonatal early onset GBS sepsis.

Results: When compared to screening and treating, universal treatment results in more women treated per GBS case prevented (155 versus 67) and prevents more cases of early onset GBS (1732 versus 1700) and neonatal deaths (52 versus 51) at a lower cost per case prevented ($8,805 versus $12,710).

Conclusion: Universal treatment of term pregnancies with a history of previous GBS colonization is more cost-effective than the strategy of screening and treating based on positive culture results.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Decision-analysis model for evaluating the cost-effectiveness of screening-directed versus universal treatment of women with group B streptococci (GBS) colonization in a previous pregnancy on prevention of early onset neonatal GBS sepsis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Schrag S, Gorwitz R, Fultz-Butts K, Schuchat A. Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC. Morbidity and Mortality Weekly Report. 2002;51(RR-11):1–22. - PubMed
    1. American College of Obstetricians and Gynecologists. ACOG Committee Opinion: number 279, December 2002. Prevention of early-onset group B streptococcal disease in newborns. Obstetrics & Gynecology. 2002;100(6):1405–1412. - PubMed
    1. Cheng P-J, Chueh H-Y, Liu C-M, Hsu J-J, Hsieh T-T, Soong Y-K. Risk factors for recurrence of group B streptococcus colonization in a subsequent pregnancy. Obstetrics & Gynecology. 2008;111(3):704–709. - PubMed
    1. Turrentine MA, Ramirez MM. Recurrence of group B streptococci colonization in subsequent pregnancy. Obstetrics & Gynecology. 2008;112(2, part 1):259–264. - PubMed
    1. Edwards RK, Clark P, Duff P. Intrapartum antibiotic prophylaxis 2: positive predictive value of antenatal group B streptococci cultures and antibiotic susceptibility of clinical isolates. Obstetrics & Gynecology. 2002;100(3):540–544. - PubMed

MeSH terms

Substances