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. 2009:2009:934698.
doi: 10.1155/2009/934698. Epub 2009 Dec 13.

Cost-effectiveness of universal prophylaxis in pregnancy with prior group B streptococci colonization

Mark A Turrentine  1 , Mildred M Ramirez, Joan M Mastrobattista
Affiliations

Cost-effectiveness of universal prophylaxis in pregnancy with prior group B streptococci colonization

Mark A Turrentine et al. Infect Dis Obstet Gynecol. 2009.

Abstract

Objective: To estimate the costs and outcomes of rescreening for group B streptococci (GBS) compared to universal treatment of term women with history of GBS colonization in a previous pregnancy.

Study design: A decision analysis model was used to compare costs and outcomes. Total cost included the costs of screening, intrapartum antibiotic prophylaxis (IAP), treatment for maternal anaphylaxis and death, evaluation of well infants whose mothers received IAP, and total costs for treatment of term neonatal early onset GBS sepsis.

Results: When compared to screening and treating, universal treatment results in more women treated per GBS case prevented (155 versus 67) and prevents more cases of early onset GBS (1732 versus 1700) and neonatal deaths (52 versus 51) at a lower cost per case prevented ($8,805 versus $12,710).

Conclusion: Universal treatment of term pregnancies with a history of previous GBS colonization is more cost-effective than the strategy of screening and treating based on positive culture results.

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Figures

Figure 1
Figure 1
Decision-analysis model for evaluating the cost-effectiveness of screening-directed versus universal treatment of women with group B streptococci (GBS) colonization in a previous pregnancy on prevention of early onset neonatal GBS sepsis.
See this image and copyright information in PMC

References

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