When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system
- PMID: 20052802
- DOI: 10.1189/jlb.0809549
When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system
Abstract
The antimicrobial effector activity of phagocytes is crucial in the host innate defense against infection, and the classic view is that the phagocytes operating against intracellular and extracellular microbial pathogens are,respectively, macrophages and neutrophils. As a result of the common origin of the two phagocytes, they share several functionalities, including avid phagocytosis,similar kinetic behavior under inflammatory/infectious conditions, and antimicrobial and immunomodulatory activities. However, consequent to specialization during their differentiation, macrophages and neutrophils acquire distinctive, complementary features that originate different levels of antimicrobial capacities and cytotoxicity and different tissue localization and lifespan.This review highlights data suggesting the perspective that the combination of overlapping and complementary characteristics of the two professional phagocytes promotes their cooperative participation as effectors and modulators in innate immunity against infection and as orchestrators of adaptive immunity. In the concerted activities operating in antimicrobial innate immunity, macrophages and neutrophils are not able to replace each other. The common and complementary developmental,kinetic, and functional properties of neutrophils and macrophages make them the effector arms of a myeloid phagocyte system that groups neutrophils with members of the old mononuclear phagocyte system. The use by mammals of a system with two dedicated phagocytic cells working cooperatively represents an advantageous innate immune attack strategy that allows the efficient and safe use of powerful but dangerous microbicidal molecules.This crucial strategy is a target of key virulence mechanisms of successful pathogens.
Similar articles
-
Neutrophils and macrophages work in concert as inducers and effectors of adaptive immunity against extracellular and intracellular microbial pathogens.J Leukoc Biol. 2010 May;87(5):805-13. doi: 10.1189/jlb.1109767. Epub 2010 Jan 28. J Leukoc Biol. 2010. PMID: 20110444 Review.
-
Macrophage phagocytosis of neutrophils at inflammatory/infectious foci: a cooperative mechanism in the control of infection and infectious inflammation.J Leukoc Biol. 2011 May;89(5):675-83. doi: 10.1189/jlb.0910536. Epub 2010 Dec 17. J Leukoc Biol. 2011. PMID: 21169518 Review.
-
Neutrophils and intracellular pathogens: beyond phagocytosis and killing.Trends Microbiol. 2007 Feb;15(2):87-92. doi: 10.1016/j.tim.2006.11.009. Epub 2006 Dec 6. Trends Microbiol. 2007. PMID: 17157505 Review.
-
Neutrophils and Immunity: From Bactericidal Action to Being Conquered.J Immunol Res. 2017;2017:9671604. doi: 10.1155/2017/9671604. Epub 2017 Feb 19. J Immunol Res. 2017. PMID: 28299345 Free PMC article. Review.
-
It takes a village: Phagocytes play a central role in fungal immunity.Semin Cell Dev Biol. 2019 May;89:16-23. doi: 10.1016/j.semcdb.2018.04.008. Epub 2018 Jun 12. Semin Cell Dev Biol. 2019. PMID: 29727727 Free PMC article. Review.
Cited by
-
Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes.Exp Biol Med (Maywood). 2021 Nov;246(22):2358-2371. doi: 10.1177/15353702211010762. Epub 2021 May 6. Exp Biol Med (Maywood). 2021. PMID: 33957802 Free PMC article. Review.
-
Liver Necrosis and Lethal Systemic Inflammation in a Murine Model of Rickettsia typhi Infection: Role of Neutrophils, Macrophages and NK Cells.PLoS Negl Trop Dis. 2016 Aug 22;10(8):e0004935. doi: 10.1371/journal.pntd.0004935. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27548618 Free PMC article.
-
Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis.Cell Mol Life Sci. 2024 Jul 13;81(1):300. doi: 10.1007/s00018-024-05311-2. Cell Mol Life Sci. 2024. PMID: 39001897 Free PMC article.
-
Deciphering mechanisms of staphylococcal biofilm evasion of host immunity.Front Cell Infect Microbiol. 2012 May 8;2:62. doi: 10.3389/fcimb.2012.00062. eCollection 2012. Front Cell Infect Microbiol. 2012. PMID: 22919653 Free PMC article. Review.
-
Macrophage Dysregulation and Impaired Skin Wound Healing in Diabetes.Front Cell Dev Biol. 2020 Jun 26;8:528. doi: 10.3389/fcell.2020.00528. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32671072 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials