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Case Reports
. 2010 Jan 7:10:1.

Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy

Jianda Yuan  1 , David B Page, Geoffrey Y Ku, Yanyun Li, Zhenyu Mu, Charlotte Ariyan, Humilidad F Gallardo, Ruth-Ann Roman, Agnes I Heine, Stephanie L Terzulli, Erika Ritter, Sacha Gnjatic, Gerd Ritter, Achim A Jungbluth, James P Allison, Lloyd J Old, Jedd D Wolchok
Affiliations
Case Reports

Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy

Jianda Yuan et al. Cancer Immun. .

Erratum in

  • Cancer Immun. 2010 Feb 24;10:5. Ritter, Erika [added]

Abstract

Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.

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