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Case Reports
. 2010 Sep;31(8):1504-5.
doi: 10.3174/ajnr.A1978. Epub 2010 Jan 6.

Abrupt regression of a meningioma after discontinuation of cyproterone treatment

A M G Gonçalves  1 , P Page, V Domigo, J-F Méder, C Oppenheim
Affiliations
Case Reports

Abrupt regression of a meningioma after discontinuation of cyproterone treatment

A M G Gonçalves et al. AJNR Am J Neuroradiol. 2010 Sep.

Abstract

The multiplicity of meningiomas or abrupt lesion growth in patients treated with cyproterone acetate suggests that this progestative treatment may promote lesion growth. We report the rapid regression of an incidental meningioma after discontinuation of a 10-year cyproterone acetate treatment. This unique observation suggests that conservative management of meningiomas may be the best option among users of high doses of cyproterone acetate, given that spontaneous regression may occur after hormonal treatment discontinuation.

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Figures

Fig 1.
Fig 1.
Extra-axial lesion of the olfactory groove, homogeneously enhanced on axial and T1-weighted sequences after administration of gadolinium and reformatted in the axial (A and B) and sagittal (C and D) planes. The lesion volume decreased rapidly from 16 cm3 (A and C) on admission to 3 cm3 (81% reduction in volume) at 3 months (not shown) and to 1.9 cm3 (88% reduction in volume) (B and D) at 6 months after hormonal treatment withdrawal.
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