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Case Reports
. 2010 Sep;31(8):1504-5.
doi: 10.3174/ajnr.A1978. Epub 2010 Jan 6.

Abrupt regression of a meningioma after discontinuation of cyproterone treatment

A M G Gonçalves  1 , P Page, V Domigo, J-F Méder, C Oppenheim
Affiliations
Case Reports

Abrupt regression of a meningioma after discontinuation of cyproterone treatment

A M G Gonçalves et al. AJNR Am J Neuroradiol. 2010 Sep.

Abstract

The multiplicity of meningiomas or abrupt lesion growth in patients treated with cyproterone acetate suggests that this progestative treatment may promote lesion growth. We report the rapid regression of an incidental meningioma after discontinuation of a 10-year cyproterone acetate treatment. This unique observation suggests that conservative management of meningiomas may be the best option among users of high doses of cyproterone acetate, given that spontaneous regression may occur after hormonal treatment discontinuation.

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Figures

Fig 1.
Fig 1.
Extra-axial lesion of the olfactory groove, homogeneously enhanced on axial and T1-weighted sequences after administration of gadolinium and reformatted in the axial (A and B) and sagittal (C and D) planes. The lesion volume decreased rapidly from 16 cm3 (A and C) on admission to 3 cm3 (81% reduction in volume) at 3 months (not shown) and to 1.9 cm3 (88% reduction in volume) (B and D) at 6 months after hormonal treatment withdrawal.
See this image and copyright information in PMC

References

    1. Froelich S, Dali-Youcef N, Boyer P, et al. . Does cyproterone acetate promote multiple meningiomas? In: Proceedings of the 10th European Congress of Endocrinology, Berlin, Germany. May 3–7, 2008
    1. Wigertz A, Lonn S, Hall P, et al. . Reproductive factors and risk of meningioma and glioma. Cancer Epidemiol Biomarkers Prev 2008;17:2663–70 - PubMed
    1. Smith JS, Quinones-Hinojosa A, Harmon-Smith M, et al. . Sex steroid and growth factor profile of a meningioma associated with pregnancy. Can J Neurol Sci 2005;32:122–27 - PubMed
    1. Blankenstein MA, Verheijen FM, Jacobs JM, et al. . Occurrence, regulation, and significance of progesterone receptors in human meningioma. Steroids 2000;65:795–800 - PubMed
    1. Hatiboglu MA, Cosar M, Iplikcioglu AC, et al. . Sex steroid and epidermal growth factor profile of giant meningiomas associated with pregnancy. Surg Neurol 2008;69:356–62 - PubMed

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