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Review
. 2010 Jan;9(1):53-64.
doi: 10.1093/bfgp/elp051. Epub 2010 Jan 6.

RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans

Zhuoyu Ni  1 , Siu Sylvia Lee
Affiliations
Review

RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans

Zhuoyu Ni et al. Brief Funct Genomics. 2010 Jan.

Abstract

Our understanding of the genetic mechanisms of organismal aging has advanced dramatically during the past two decades. With the development of large-scale RNAi screens, the last few years saw the remarkable identifications of hundreds of new longevity genes in the roundworm Caenorhabditis elegans. The various RNAi screens revealed many biological pathways previously unknown to be related to aging. In this review, we focus on findings from the recent large-scale RNAi longevity screens, and discuss insights they have provided into the complex biological process of aging and considerations of the RNAi technology will continue to have on the future development of the aging field.

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References

    1. Johnson TE. Caenorhabditis elegans 2007: the premier model for the study of aging. Exp Gerontol. 2008;43:1–4. - PMC - PubMed
    1. Olsen A, Vantipalli MC, Lithgow GJ. Using Caenorhabditis elegans as a model for aging and age-related diseases. Ann NY Acad Sci. 2006;1067:120–8. - PubMed
    1. Klass MR. A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech Ageing Dev. 1983;22:279–86. - PubMed
    1. Friedman DB, Johnson TE. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics. 1988;118:75–86. - PMC - PubMed
    1. Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 1996;382:536–9. - PubMed

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