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Case Reports
. 2010 Mar;24(3):666-8.
doi: 10.1038/leu.2009.275. Epub 2010 Jan 7.

Failure is not fatal: long-term remission in refractory acute myeloid leukemia (AML) after graft failure of cord blood stem cells

J A Burger, N S Velev, E J Jabbour, W G Wierda, F Ravandi, J E Cortes, H Kantarjian, Y L Nieto, E J Shpall, J L Jorgensen
Case Reports

Failure is not fatal: long-term remission in refractory acute myeloid leukemia (AML) after graft failure of cord blood stem cells

J A Burger et al. Leukemia. 2010 Mar.
No abstract available

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Conflict of interest statement

Disclaimer: The authors state that they have no conflict of interest related to this article

Figures

Figure 1:
Figure 1:
Bone marrow morphology before (A, B) and after cord blood stem cell transplantation (C, D). Fig. 1 A and B depict bone marrow aspirate smears at the initial presentation with myeloblasts in a background of dysplastic erythroid and myeloid elements (Wright-Giemsa stains, photographed at 1000x). Fig. 1 C and D display photomicrographs of bone marrow aspirate smears after CB-SCT that are consistent with a complete remission and that depict scattered large granular lymphocytes (black arrows) in a background of mildly dysplastic myeloid cells, some with hypogranular cytoplasm (blue arrow).
Figure 2:
Figure 2:
Expansion of autologous, CD8+ T cells after CB-SCT. Fig. 2A depicts the kinetics of the lymphocytosis after non-myeloablative conditioning with FC, ATG and TBI, and subsequent CB-SCT (indicated by the arrow). Fig. 2B illustrates the immunophenotype of the expanded T cells. Displayed are the forward (FSC) and sideward scatter (SSC) characteristics with gating on the lymphocyte population (left hand box), and staining with anti-CD3 and anti-CD8 mAbs, revealing that 83.3% of the lymphocytes were CD8 positive (center box). Staining with anti-CD57 and anti-CD94 mAbs (right hand box) also revealed that these CD8+ T cells displayed a phenotype consistent with large granular lymphocytes (LGL), which is in keeping with the morphology of these activated lymphocytes (Fig. 1C, D).
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