Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2010 Mar;24(3):666-8.
doi: 10.1038/leu.2009.275. Epub 2010 Jan 7.

Failure is not fatal: long-term remission in refractory acute myeloid leukemia (AML) after graft failure of cord blood stem cells

J A Burger, N S Velev, E J Jabbour, W G Wierda, F Ravandi, J E Cortes, H Kantarjian, Y L Nieto, E J Shpall, J L Jorgensen
Case Reports

Failure is not fatal: long-term remission in refractory acute myeloid leukemia (AML) after graft failure of cord blood stem cells

J A Burger et al. Leukemia. 2010 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Disclaimer: The authors state that they have no conflict of interest related to this article

Figures

Figure 1:
Figure 1:
Bone marrow morphology before (A, B) and after cord blood stem cell transplantation (C, D). Fig. 1 A and B depict bone marrow aspirate smears at the initial presentation with myeloblasts in a background of dysplastic erythroid and myeloid elements (Wright-Giemsa stains, photographed at 1000x). Fig. 1 C and D display photomicrographs of bone marrow aspirate smears after CB-SCT that are consistent with a complete remission and that depict scattered large granular lymphocytes (black arrows) in a background of mildly dysplastic myeloid cells, some with hypogranular cytoplasm (blue arrow).
Figure 2:
Figure 2:
Expansion of autologous, CD8+ T cells after CB-SCT. Fig. 2A depicts the kinetics of the lymphocytosis after non-myeloablative conditioning with FC, ATG and TBI, and subsequent CB-SCT (indicated by the arrow). Fig. 2B illustrates the immunophenotype of the expanded T cells. Displayed are the forward (FSC) and sideward scatter (SSC) characteristics with gating on the lymphocyte population (left hand box), and staining with anti-CD3 and anti-CD8 mAbs, revealing that 83.3% of the lymphocytes were CD8 positive (center box). Staining with anti-CD57 and anti-CD94 mAbs (right hand box) also revealed that these CD8+ T cells displayed a phenotype consistent with large granular lymphocytes (LGL), which is in keeping with the morphology of these activated lymphocytes (Fig. 1C, D).
See this image and copyright information in PMC

References

    1. Daccache A, Kizhakekuttu T, Siebert J, Veeder M. Hematologic and cytogenetic spontaneous remission in acute monocytic leukemia (FAB M5b) with trisomy 8. J Clin Oncol 2007. Jan 20; 25(3): 344–346. - PubMed
    1. Delmer A, Heron E, Marie JP, Zittoun R. Spontaneous remission in acute myeloid leukaemia. Br J Haematol 1994. Aug; 87(4): 880–882. - PubMed
    1. Mitterbauer M, Fritzer-Szekeres M, Mitterbauer G, Simonitsch I, Knobl P, Rintelen C, et al. Spontaneous remission of acute myeloid leukemia after infection and blood transfusion associated with hypergammaglobulinaemia. Ann Hematol 1996. Oct; 73(4): 189–193. - PubMed
    1. Narayanan MN, Lewis MJ. Spontaneous complete remission of acute myeloid leukaemia with interstitial deletion of chromosome 5. Clinical and laboratory haematology 1991; 13(4): 391–395. - PubMed
    1. Muller CI, Trepel M, Kunzmann R, Lais A, Engelhardt R, Lubbert M. Hematologic and molecular spontaneous remission following sepsis in acute monoblastic leukemia with translocation (9;11): a case report and review of the literature. European journal of haematology 2004. Jul; 73(1): 62–66. - PubMed