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Review
. 2009 Dec 10;10(12):5326-5349.
doi: 10.3390/ijms10125326.

The hunt for natural skin whitening agents

Nico Smit  1 , Jana Vicanova  2 , Stan Pavel  3
Affiliations
Review

The hunt for natural skin whitening agents

Nico Smit et al. Int J Mol Sci. .

Abstract

Skin whitening products are commercially available for cosmetic purposes in order to obtain a lighter skin appearance. They are also utilized for clinical treatment of pigmentary disorders such as melasma or postinflammatory hyperpigmentation. Whitening agents act at various levels of melanin production in the skin. Many of them are known as competitive inhibitors of tyrosinase, the key enzyme in melanogenesis. Others inhibit the maturation of this enzyme or the transport of pigment granules (melanosomes) from melanocytes to surrounding keratinocytes. In this review we present an overview of (natural) whitening products that may decrease skin pigmentation by their interference with the pigmentary processes.

Keywords: cosmetics; natural agents; tyrosinase inhibitors; whitening.

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References

    1. Cooksey CJ, Garratt PJ, Land EJ, Pavel S, Ramsden CA, Riley PA, Smit NP. Evidence of the indirect formation of the catecholic intermediate substrate responsible for the autoactivation kinetics of tyrosinase. J. Biol. Chem. 1997;272:26226–26235. - PubMed
    1. Riley PA. Hydroxyanisole depigmentation: In-vitro studies. J. Pathol. 1969;97:193–206. - PubMed
    1. Riley PA. Hydroxyanisole depigmentation: In-vivo studies. J. Pathol. 1969;97:185–191. - PubMed
    1. Naish-Byfield S, Cooksey CJ, Latter AM, Johnson CI, Riley PA. In vitro assessment of the structure-activity relationship of tyrosinase-dependent cytotoxicity of a series of substituted phenols. Melanoma. Res. 1991;1:273–287. - PubMed
    1. Smit NP, Peters K, Menko W, Westerhof W, Pavel S, Riley PA. Cytotoxicity of a selected series of substituted phenols towards cultured melanoma cells. Melanoma Res. 1992;2:295–304. - PubMed

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