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Review
. 2009 Dec 18;10(12):5411-5441.
doi: 10.3390/ijms10125411.

Cell culture on MEMS platforms: a review

Ming Ni  1 , Wen Hao Tong  1   2 , Deepak Choudhury  1   2 , Nur Aida Abdul Rahim  3 , Ciprian Iliescu  1 , Hanry Yu  1   2   3   4   5
Affiliations
Review

Cell culture on MEMS platforms: a review

Ming Ni et al. Int J Mol Sci. .

Abstract

Microfabricated systems provide an excellent platform for the culture of cells, and are an extremely useful tool for the investigation of cellular responses to various stimuli. Advantages offered over traditional methods include cost-effectiveness, controllability, low volume, high resolution, and sensitivity. Both biocompatible and bio-incompatible materials have been developed for use in these applications. Biocompatible materials such as PMMA or PLGA can be used directly for cell culture. However, for bio-incompatible materials such as silicon or PDMS, additional steps need to be taken to render these materials more suitable for cell adhesion and maintenance. This review describes multiple surface modification strategies to improve the biocompatibility of MEMS materials. Basic concepts of cell-biomaterial interactions, such as protein adsorption and cell adhesion are covered. Finally, the applications of these MEMS materials in Tissue Engineering are presented.

Keywords: MEMS platforms; biocompatibility; biomaterials; cell culture.

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Figures

Figure 1.
Figure 1.
Schematic diagram of a perfusion system.
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References

    1. Manz A, Becker H. Microsystem Technology in Chemistry and Life Sciences. Springer; New York, NY, USA: 1999.
    1. Ziaie B, Baldi A, Lei M, Gu Y, Siegel RA. Hard and soft micromachining for BioMEMS: review of techniques and examples of applications in microfluidics and drug delivery. Adv. Drug. Deliv. Rev. 2004;56:145–172. - PubMed
    1. Kohler JM, Mejevaia T, Saluz HP. Microsystem Technology: A Powerful Tool for Biomolecular Studies. Birkhauser; Boston, MA, USA: 1999.
    1. Grayson AC, Shawgo RS, Johnson AM, Flynn NT, Li Y, Cima MJ, Langer R. A BioMEMS review: MEMS technology for physiologically integrated devices. Proc. IEEE. 2004;92:6–21.
    1. West J, Becker M, Tombrink S, Manz A. Micro total analysis systems: latest achievements. Anal. Chem. 2008;80:4403–4419. - PubMed

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