Review
[Advances in the study of affinity selection-ultrafiltration/HPLC-MS]
[Article in
Chinese]
Affiliations
- PMID: 20055128
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Review
[Advances in the study of affinity selection-ultrafiltration/HPLC-MS]
[Article in
Chinese]
Yao Xue Xue Bao.
2009 Oct.
Abstract
Affinity selection-ultrafiltration/HPLC-MS is the combination of the ultrafiltration and HPLC-MS, mainly used for screening small active molecular substances from combinatorial libraries and natural product extracts, which can bind to solution-phase targets. Besides, it can be used in metabolic screening and characterization of ligand-receptor binding. It is a complement to the traditional methods of screening and identifying drugs. This review describes its principle and application in drug study.
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