Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010:50:323-54.
doi: 10.1146/annurev.pharmtox.010909.105600.

Mechanisms of cell protection by heme oxygenase-1

Raffaella Gozzelino  1 , Viktoria Jeney, Miguel P Soares
Affiliations
Review

Mechanisms of cell protection by heme oxygenase-1

Raffaella Gozzelino et al. Annu Rev Pharmacol Toxicol. 2010.

Abstract

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe(2+), carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism underlying this cytoprotective effect relies on the ability of HO-1 to catabolize free heme and prevent it from sensitizing cells to undergo programmed cell death. This cytoprotective effect inhibits the pathogenesis of a variety of immune-mediated inflammatory diseases.

PubMed Disclaimer

Publication types

LinkOut - more resources