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. 1977 Nov;18(2):352-5.
doi: 10.1128/iai.18.2.352-355.1977.

New test for endotoxin potency based upon histamine sensitization in mice

R K Bergman, K C Milner, J J Munoz

New test for endotoxin potency based upon histamine sensitization in mice

R K Bergman et al. Infect Immun. 1977 Nov.

Abstract

The results of a test of endotoxic potency based upon the development of histamine hypersensitivity in mice were compared with the results obtained by testing the same materials for pyrogenicity in rabbits and lethality for chicken embryos (CELD50). The results of the histamine hypersensitization test (HHT) correlated well with those of the other two tests. The sensitivity of the HHT was about the same as that of the CELD50 assay. The HHT may provide a relatively inexpensive, fast, and reliable assay method for endotoxin laboratories that do not have the facilities for the more elaborate assays.

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References

    1. Infect Immun. 1977 Jan;15(1):72-7 - PubMed
    1. J Clin Microbiol. 1976 Jan;3(1):21-5 - PubMed
    1. Proc Soc Exp Biol Med. 1968 Apr;127(4):999-1003 - PubMed
    1. J Bacteriol. 1969 Oct;100(1):140-8 - PubMed
    1. J Immunol. 1967 Jan;98(1):1-7 - PubMed

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