Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2010 Feb 1;20(3):1040-4.
doi: 10.1016/j.bmcl.2009.12.045. Epub 2009 Dec 16.

Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

Sumesh Eswaran  1 , Airody Vasudeva Adhikari, Nishith K Pal, Imran H Chowdhury
Affiliations
Comparative Study

Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

Sumesh Eswaran et al. Bioorg Med Chem Lett. .

Abstract

A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC(2)), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources