Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Dec;5(4):319-27.
doi: 10.1007/s12015-009-9096-7.

Building a framework for embryonic microenvironments and cancer stem cells

Antonio Ruiz-Vela  1 , Cristóbal Aguilar-Gallardo, Carlos Simón
Affiliations
Review

Building a framework for embryonic microenvironments and cancer stem cells

Antonio Ruiz-Vela et al. Stem Cell Rev Rep. 2009 Dec.

Abstract

The putative existence of a cancer stem cell niche consisting of bi-directional stromal and stem cell secreting factors that trigger cancer stem cell growth and proliferation has been hypothesized in the nervous and hematopoietic systems. In light of this theory, it has been proposed that embryonic stem cell microenvironments, upon interactions with cancer stem cells, may reprogram cancer cells resulting in a substantial inhibition of tumor cell properties. Here, we discuss emerging data that support this novel concept of cancer inhibitory factors produced in the context of embryonic microenvironments as well as by embryonic stem cells (ESCs).

PubMed Disclaimer

References

    1. Cell. 2007 Feb 23;128(4):747-62 - PubMed
    1. Cell. 2004 Mar 19;116(6):769-78 - PubMed
    1. Cancer Res. 2006 Aug 15;66(16):7843-8 - PubMed
    1. Nature. 1994 Feb 17;367(6464):645-8 - PubMed
    1. Nature. 2005 Jun 9;435(7043):752-3 - PubMed

LinkOut - more resources