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. 1991 Apr;11(4):2291-5.
doi: 10.1128/mcb.11.4.2291-2295.1991.

Transcriptional suppression of cellular gene expression by c-Myc

B S Yang  1 , T J Geddes, R J Pogulis, B de Crombrugghe, S O Freytag
Affiliations

Transcriptional suppression of cellular gene expression by c-Myc

B S Yang et al. Mol Cell Biol. 1991 Apr.

Abstract

High levels of c-Myc in mouse 3T3-L1 cells specifically suppress the expression of three collagen genes. This effect is exerted through collagen promoter sequences and requires the leucine zipper motif of c-Myc. Our data suggest that an important aspect of c-Myc transforming activity is the ability to suppress specific cellular gene transcription.

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