doi: 10.1128/mcb.11.4.2303-2306.1991.
The C/EBP-binding region and adjacent sites regulate expression of the adipose P2 gene in human preadipocytes
Affiliations
- PMID: 2005913
- PMCID: PMC359935
- DOI: 10.1128/mcb.11.4.2303-2306.1991
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The C/EBP-binding region and adjacent sites regulate expression of the adipose P2 gene in human preadipocytes
Mol Cell Biol.
1991 Apr.
Abstract
Human preadipocytes contain nuclear factors that specifically bind to the AE-1 sequence, previously demonstrated as an enhancer element in the regulation of adipose P2 gene expression during 3T3 adipose differentiation. By transient transfection and in vivo competition experiments, the trans-acting factors were found to bind either to the C/EBP recognition site in the AE-1 sequence and act as a negative regulator or to the adjacent site (termed 3' AE-1) and act as a positive regulator of adipose P2 gene activity in human preadipocytes.
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