Defending the genome in tudor style
- PMID: 20059942
- DOI: 10.1016/j.devcel.2009.11.007
Defending the genome in tudor style
Abstract
Repression of transposable elements is crucial for the survival of germ cells. In this issue of Developmental Cell, Shoji et al. provide evidence that a Tudor domain protein TDRD9 partners with MIWI2 to specifically silence LINE-1 transposons in the fetal germline of male mice.
2009 Elsevier Inc. All rights reserved.
Comment on
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The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.Dev Cell. 2009 Dec;17(6):775-87. doi: 10.1016/j.devcel.2009.10.012. Dev Cell. 2009. PMID: 20059948
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