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Review
. 2010 Jan;11(1):15-29.
doi: 10.1093/bib/bbp057. Epub 2010 Jan 8.

Toward the dynamic interactome: it's about time

Teresa M Przytycka  1 , Mona Singh, Donna K Slonim
Affiliations
Review

Toward the dynamic interactome: it's about time

Teresa M Przytycka et al. Brief Bioinform. 2010 Jan.

Abstract

Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different times and conditions, is increasingly helpful in elucidating interaction dynamics. Here we review the beginnings of a new subfield within computational biology, one focused on the global inference and analysis of the dynamic interactome. This burgeoning research area, which entails a shift from static to dynamic network analysis, promises to be a major step forward in our ability to model and reason about cellular function and behavior.

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References

    1. Ito T, Chiba T, Ozawa R, et al. A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci USA. 2001;98:4569–74. - PMC - PubMed
    1. Uetz P, Giot L, Cagney G, et al. A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae. Nature. 2000;403:623–7. - PubMed
    1. Ho Y, Gruhler A, Heilbut A, et al. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002;415:180–3. - PubMed
    1. Gavin AC, Aloy P, Grandi P, et al. Proteome survey reveals modularity of the yeast cell machinery. Nature. 2006;440:631–6. - PubMed
    1. Krogan NJ, Cagney G, Yu H, et al. Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006;440:637–43. - PubMed

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