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. 2010 Feb 15;171(4):455-64.
doi: 10.1093/aje/kwp404. Epub 2010 Jan 8.

Pesticide use and thyroid disease among women in the Agricultural Health Study

Whitney S Goldner  1 , Dale P Sandler, Fang Yu, Jane A Hoppin, Freya Kamel, Tricia D Levan
Affiliations

Pesticide use and thyroid disease among women in the Agricultural Health Study

Whitney S Goldner et al. Am J Epidemiol. .

Abstract

Thyroid disease is common, and evidence of an association between organochlorine exposure and thyroid disease is increasing. The authors examined the cross-sectional association between ever use of organochlorines and risk of hypothyroidism and hyperthyroidism among female spouses (n = 16,529) in Iowa and North Carolina enrolled in the Agricultural Health Study in 1993-1997. They also assessed risk of thyroid disease in relation to ever use of herbicides, insecticides, fungicides, and fumigants. Prevalence of self-reported clinically diagnosed thyroid disease was 12.5%, and prevalence of hypothyroidism and hyperthyroidism was 6.9% and 2.1%, respectively. There was an increased odds of hypothyroidism with ever use of organochlorine insecticides (adjusted odds ratio (OR(adj)) = 1.2 (95% confidence interval (CI): 1.0, 1.6) and fungicides (OR(adj) = 1.4 (95% CI: 1.1, 1.8) but no association with ever use of herbicides, fumigants, organophosphates, pyrethroids, or carbamates. Specifically, ever use of the organochlorine chlordane (OR(adj) = 1.3 (95% CI: 0.99, 1.7), the fungicides benomyl (OR(adj) = 3.1 (95% CI: 1.9, 5.1) and maneb/mancozeb (OR(adj) = 2.2 (95% CI: 1.5, 3.3), and the herbicide paraquat (OR(adj) = 1.8 (95% CI: 1.1, 2.8) was significantly associated with hypothyroidism. Maneb/mancozeb was the only pesticide associated with both hyperthyroidism (OR(adj) = 2.3 (95% CI: 1.2, 4.4) and hypothyroidism. These data support a role of organochlorines, in addition to fungicides, in the etiology of thyroid disease among female spouses enrolled in the Agricultural Health Study.

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Figures

Figure 1.
Figure 1.
Selection of the study population, Agricultural Health Study, 1993–1997. Female spouses of licensed pesticide applicators in Iowa and North Carolina who were part of the Agricultural Health Study and who also had thyroid disease and pesticide use data were included. For further analysis, the population was then divided into 4 groups: no thyroid disease, hyperthyroid, hypothyroid, and other.
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References

    1. Canaris GJ, Manowitz NR, Mayor G, et al. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160(4):526–534. - PubMed
    1. Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III) J Clin Endocrinol Metab. 2002;87(2):489–499. - PubMed
    1. Vanderpump M, Tunbridge W. The epidemiology of thyroid disease. In: Braverman L, Utiger R, editors. The Thyroid. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2000. pp. 467–473.
    1. Baskin HJ, Cobin RH, Duick DS, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract. 2002;8(6):457–469. - PubMed
    1. Delange F. Endemic cretinism. In: Braverman L, Utiger R, editors. The Thyroid. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2000. pp. 743–754.

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