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. 2009 Dec 16:2:9329.
doi: 10.1186/1757-1626-2-9329.

Safety of trastuzumab (Herceptin) during pregnancy: two case reports

Matthew J Goodyer  1 , Jeffri Rm Ismail, Seamus P O'Reilly, Eugene J Moylan, C Anthony M Ryan, Paul Af Hughes, Alan O'Connor
Affiliations

Safety of trastuzumab (Herceptin) during pregnancy: two case reports

Matthew J Goodyer et al. Cases J. .

Abstract

We report on two cases of women on trastuzumab therapy for breast cancer who became pregnant and delivered healthy live infants. At the time of reporting the children are growing and developing normally (ages 3 and 2).

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References

    1. Simister NE. Placental transport of immunoglobulin G. Vaccine. 2003;21:3365–9. doi: 10.1016/S0264-410X(03)00334-7. cited by Mir O, Berveiller P, Pons G: Trastuzumab - mechanism of action and use. N Engl J Med 2007, 357(16):1664-5. - DOI - PubMed
    1. Friedrichs B, Tiemann M, Salwender H, Verpoort K, Wenger MK, Schmitz N. The effects of rituximab treatment during pregnancy on a neonate. Haematologica. 2006;91:1426–7. cited by Mir O, Berveiller P, Pons G: Trastuzumab - mechanism of action and use. N Engl J Med 2007, 357(16):1664-5. - PubMed
    1. Vasiliauskas EA, Church JA, Silverman N, Barry M, Targan SR, Dubinksy MC. Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn. Clin Gastroenterol Hepatol. 2006;4:1255–8. doi: 10.1016/j.cgh.2006.07.018. cited by Mir O, Berveiller P, Pons G: Trastuzumab - mechanism of action and use. N Engl J Med 2007, 357(16):1664-5. - DOI - PubMed
    1. Bader AA, Schlembach D, Tamussino KF, Pristauz G, Petru E. Anhydramnios associated with administration of trastuzumab and paclitaxel for metastatic breast cancer during pregnancy. Lancet Oncology. 2007;8(1):79–81. doi: 10.1016/S1470-2045(06)71014-2. - DOI - PubMed
    1. Watson WJ. Herceptin (trastuzumab) therapy during pregnancy: association with reversible anhydramnios. Obstetrics and Gynecology. 2005;105(3):642–3. - PubMed

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