Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jan 11:6:2.
doi: 10.1186/1746-6148-6-2.

A single vaccination with an inactivated bovine respiratory syncytial virus vaccine primes the cellular immune response in calves with maternal antibody

Mirjam T W van der Sluijs  1 , Eva M Kuhn, Birgit Makoschey
Affiliations

A single vaccination with an inactivated bovine respiratory syncytial virus vaccine primes the cellular immune response in calves with maternal antibody

Mirjam T W van der Sluijs et al. BMC Vet Res. .

Abstract

Background: The efficacy of a single dose of an inactivated bovine respiratory syncytial virus (BRSV)--Parainfluenaza type 3 (PI3)--Mannheimia haemolytica (Mh) combination vaccine, in calves positive for maternal antibodies, was established in a BRSV infection study.

Results: As expected the single vaccination did not have any effect on the decline of BRSV-specific neutralising or ELISA antibody. The cellular immune system was however primed by the vaccination. In the vaccinated group virus excretion with nasal discharge was reduced, less virus could be re-isolated from lung tissues and the lungs were less affected.

Conclusions: These results indicate that a single vaccination with an inactivated BRSV vaccine was able to break through the maternal immunity and induce partial protection in very young calves. It can be speculated that the level and duration of protection will improve after the second dose of vaccine is administered. A two-dose basic vaccination schedule is recommended under field conditions.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Baker JC. The clinical manifestation of bovine viral diarrhea infection. Vet Clin N Am Food Animal Practice. 1995;11:425–445. - PubMed
    1. Babiuk LA, Lawman MJ, Ohmann HB. Viral-bacterial synergistic interaction in respiratory disease. Adv Virus Res. 1988;35:219–249. full_text. - PMC - PubMed
    1. Castleman WL, Lay JC, Dubovi EJ, Slauson DO. Experimental bovine respiratory syncytial virus infection in conventional calves: Light microscopic lesions, microbiology, and studies on lavaged lung cells. Am J Vet Res. 1985;46:547–553. - PubMed
    1. Ciszewski DK, Baker JC, Slocombe RF, Reindel JF, Haines DM, Clark EG. Experimental reproduction of respiratory tract disease with bovine respiratory syncytial virus. Vet Microbiol. 1991;28:39–60. doi: 10.1016/0378-1135(91)90098-Z. - DOI - PubMed
    1. Knott I, Weynants V, Walravens K, Poel WHM Van der, Kramps JA, Letesson JJ. Immune response of calves experimentally infected with non-cell-culture-passaged bovine respiratory syncytial virus. Archives of Virology. 1998;143:1119–1128. doi: 10.1007/s007050050360. - DOI - PubMed

MeSH terms