doi: 10.1016/j.cell.2009.12.016.
Integrins and mutant p53 on the road to metastasis
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- PMID: 20064366
- DOI: 10.1016/j.cell.2009.12.016
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Integrins and mutant p53 on the road to metastasis
Cell.
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Free article
Abstract
Understanding how tumor cells invade tissues is key to developing drugs to block metastasis. In this issue, Muller et al. (2009) report that a mutant form of the tumor suppressor p53 in cancer cells boosts the endocytic recycling of the adhesion molecule integrin alpha5beta1 and of epidermal growth factor receptor, promoting invasion and metastasis.
Copyright 2009 Elsevier Inc. All rights reserved.
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