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. 2009 Dec 24;64(6):771-3.
doi: 10.1016/j.neuron.2009.12.017.

alpha-synuclein and LRRK2: partners in crime

Youren Tong  1 , Jie Shen
Affiliations

alpha-synuclein and LRRK2: partners in crime

Youren Tong et al. Neuron. .

Abstract

In this issue of Neuron, Lin et al. report that LRRK2 modulates age-related neurodegeneration caused by overexpression of alpha-synuclein in the forebrain of transgenic mice. Overexpression of LRRK2 accelerates the progression of alpha-synuclein-mediated neuropathological changes, whereas deletion of LRRK2 alleviates these alterations. The results reveal an interesting interaction between alpha-synuclein and LRRK2, two gene products linked to dominantly inherited Parkinson's disease.

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