Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Dec 25;36(6):920-1.
doi: 10.1016/j.molcel.2009.12.013.

HuD stimulates translation via eIF4A

Chyi-Ying A Chen  1 , Ann-Bin Shyu
Affiliations
Comment

HuD stimulates translation via eIF4A

Chyi-Ying A Chen et al. Mol Cell. .

Abstract

In this issue of Molecular Cell, Fukao et al. (2009) report that HuD upregulates mRNA translation through direct interaction with eIF4A in the 5' cap-binding complex, revealing a posttranscriptional role for HuD in neuronal development and plasticity.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Models for HuD-mediated translation enhancement
(A) General translation enhancement. This model proposes that HuD functions as an autonomous translation activator through its interactions with eIF4A and the poly(A) tail. (B) Transcript-specific translation enhancement. This model proposes that HuD first associates with mRNA targets through binding to AU-rich or U-rich sequences (e.g., ARE) in the 3' UTRs to exert its translation enhancing effect.
See this image and copyright information in PMC

Comment on

References

    1. Akamatsu W, Fujihara H, Mitsuhashi T, Yano M, Shibata S, Hayakawa Y, Okano HJ, Sakakibara S, Takano H, Takano T, Takahashi T, Noda T, Okano H. Proc Natl Acad Sci USA. 2005;102:4625–30. - PMC - PubMed
    1. Anderson KD, Sengupta J, Morin M, Neve RL, Valenzuela CF, Perrone-Bizzozero NI. Experimental Neurology. 2001;168:250–258. - PubMed
    1. Bolognani F, Contente-Cuomo T, Perrone-Bizzozero NI. Nucl Acids Res. 2009 October 21; [Epub ahead of print] - PMC - PubMed
    1. DeschÍnes-Furry J, Perrone-Bizzozero NI, Bernard JJ. BioEssays. 2006;28:822–833. - PubMed
    1. Fukao A, Sasano Y, Imataka H, Inoue K, Sakamoto H, Sonenberg N, Thoma C, Fujiwara T. Mol Cell. 2009 this issue. - PubMed