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. 2010 Mar 11;28(12):2465-71.
doi: 10.1016/j.vaccine.2009.12.075. Epub 2010 Jan 9.

Staphylococcus aureus vaccine for orthopedic patients: an economic model and analysis

Bruce Y Lee  1 , Ann E Wiringa, Rachel R Bailey, G Jonathan Lewis, Jared Feura, Robert R Muder
Affiliations

Staphylococcus aureus vaccine for orthopedic patients: an economic model and analysis

Bruce Y Lee et al. Vaccine. .

Abstract

To evaluate the potential economic value of a Staphylococcus aureus vaccine for pre-operative orthopedic surgery patients, we developed an economic computer simulation model. At MRSA colonization rates as low as 1%, a $50 vaccine was cost-effective [<or=$50,000 per quality-adjusted life year (QALY) saved] at vaccine efficacy >or=30%, and a $100 vaccine at vaccine efficacy >or=70%. High MRSA prevalence (>or=25%) could justify a vaccine price as high as $1000. Our results suggest that a S. aureus vaccine for the pre-operative orthopedic population would be very cost-effective over a wide range of MRSA prevalence and vaccine efficacies and costs.

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Figures

FIGURE 1
FIGURE 1
General model structure.
FIGURE 2
FIGURE 2
MRSA infection outcomes subtree.
FIGURE 3
FIGURE 3
Incremental cost-effectiveness ratios (ICERs): vaccinating orthopedic surgery patients for S. aureus with a $50 vaccine.
See this image and copyright information in PMC

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