Myeloperoxidase levels and mortality in frail community-living elderly individuals
- PMID: 20064836
- PMCID: PMC4345789
- DOI: 10.1093/gerona/glp183
Myeloperoxidase levels and mortality in frail community-living elderly individuals
Abstract
Background: Elevated systemic levels of myeloperoxidase (MPO) have been associated with unfavourable clinical outcomes. In the present study, we evaluate the impact of MPO, a pro-oxidant enzyme that catalyzes the initiation of lipid peroxidation and affects nitric oxide levels, on the risk of all-cause mortality in a large population of frail octogenarians and nonagenarians living in community.
Methods: We analyzed data from the Aging and Longevity Study in the Sirente Geographic Area (ilSIRENTE Study), a prospective cohort study that collected data on all individuals aged 80 years and older living in a mountain community (n = 363). The main outcome measure was the risk of death after 4 years of follow-up. Participants were divided into three groups based on MPO tertiles: lower tertile < or = 61.5 microg/L (n = 120), intermediate tertile 61.6-140.6 microg/L (n = 120), and higher tertile > or = 140.7 microg/L (n = 123).
Results: A total of 150 deaths occurred during 4-years follow-up. The mean MPO level was 170.8 + or - 177.5 microg/L among those who died compared with 135.4 + or - 142.4 microg/L among survivors (p = .03). Individuals in the highest MPO tertile had higher risk of mortality (40% [60/123]) compared with those in the lower tertile (26% [39/120]). After adjusting for potential confounders, compared with participants in the lower tertile, those in the higher tertile had a hazard ratio for mortality of 1.97 (95% confidence interval: 1.02-3.80).
Conclusion: Our results obtained from a representative sample of very old and frail elderly individuals expand the knowledge that low levels of MPO are associated with better survival.
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References
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- Zhang R, Brennan ML, Shen Z, et al. Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation. J Biol Chem. 2002;277:46116–46122. - PubMed
-
- Miquel J, Ramirez-Bosca A, Soler A, et al. Increase with age of serum lipid peroxides: implications for the prevention of atherosclerosis. Mech Ageing Dev. 1998;100:17–24. - PubMed
-
- Hazen SL, Gaut JP, Crowley JR, Hsu FF, Heinecke JW. Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions. Biochem J. 2000;352(pt 3):693–699. - PMC - PubMed
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