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. 2010 Jan;82(1):145-7.
doi: 10.4269/ajtmh.2010.09-0408.

Utility of a point-of-care malaria rapid diagnostic test for excluding malaria as the cause of fever among HIV-positive adults in rural Rakai, Uganda

Lisa A Mills  1 , Joseph Kagaayi, Gertrude Nakigozi, Ronald M Galiwango, Joseph Ouma, Joseph P Shott, Victor Ssempijja, Ronald H Gray, Maria J Wawer, David Serwadda, Thomas C Quinn, Steven J Reynolds
Affiliations

Utility of a point-of-care malaria rapid diagnostic test for excluding malaria as the cause of fever among HIV-positive adults in rural Rakai, Uganda

Lisa A Mills et al. Am J Trop Med Hyg. 2010 Jan.

Abstract

We compared results of a malaria rapid diagnostic test (Binax Now Malaria, Binax-M, Inverness Medical Innovations, Inc., Waltham, MA) performed at rural mobile clinics in Uganda by clinicians evaluating febrile adult HIV patients to thick smear evaluated at a central laboratory by trained microscopists. Two hundred forty-six samples were analyzed, including 14 (5.7%) which were thick-smear positive for falciparum malaria. Sensitivity of Binax-M compared with thick smear was 85.7% (95% CI: 57.2-98.2), specificity 97.8% (95% CI: 94.9-99.3), positive and negative predictive values were 70.6% (95% CI: 44.0-89.7) and 99.1% (95% CI: 96.8-99.9), respectively. The rapid diagnostic test accurately ruled malaria "in or out" at the point-of-care, facilitating appropriate clinical management and averting unnecessary anti-malarial therapy.

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Comment in

  • Utility of point-of-care malaria rapid diagnostic tests.
    Van den Ende J, Jacobs J, Bisoffi Z. Van den Ende J, et al. Am J Trop Med Hyg. 2010 Jul;83(1):207; author reply 208. doi: 10.4269/ajtmh.2010.10-0114a. Am J Trop Med Hyg. 2010. PMID: 20595503 Free PMC article. No abstract available.

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