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. 2010:2010:414676.
doi: 10.1155/2010/414676. Epub 2009 Dec 28.

Targeting the EGF receptor for ovarian cancer therapy

Reema Zeineldin  1 , Carolyn Y Muller, M Sharon Stack, Laurie G Hudson
Affiliations

Targeting the EGF receptor for ovarian cancer therapy

Reema Zeineldin et al. J Oncol. 2010.

Abstract

Ovarian carcinoma is the leading cause of death from gynecologic malignancy in the US. Factors such as the molecular heterogeneity of ovarian tumors and frequent diagnosis at advanced stages hamper effective disease treatment. There is growing emphasis on the identification and development of targeted therapies to disrupt molecular pathways in cancer. The epidermal growth factor (EGF) receptor is one such protein target with potential utility in the management of ovarian cancer. This paper will discuss contributions of EGF receptor activation to ovarian cancer pathogenesis and the status of EGF receptor inhibitors and EGF receptor targeted therapies in ovarian cancer treatment.

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References

    1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA: Cancer Journal for Clinicians. 2008;58(2):71–96. - PubMed
    1. Bast RC, Jr., Hennessy B, Mills GB. The biology of ovarian cancer: new opportunities for translation. Nature Reviews Cancer. 2009;9(6):415–428. - PMC - PubMed
    1. Scully R, Young R, Clement P. Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament. In: Rosia J, Sobin L, editors. Atlas of Tumor Pathology. Fascicle 23. Washington, DC, USA: Armed Forces Institute of Pathlogy; 1998.
    1. Yap TA, Carden CP, Kaye SB. Beyond chemotherapy: targeted therapies in ovarian cancer. Nature Reviews Cancer. 2009;9(3):167–181. - PubMed
    1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57–70. - PubMed

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