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Review
. 2010 Feb;88(2):143-7.
doi: 10.1007/s00109-009-0574-9.

Genome-based approaches to vaccine development

Marirosa Mora  1 , John L Telford
Affiliations
Review

Genome-based approaches to vaccine development

Marirosa Mora et al. J Mol Med (Berl). 2010 Feb.

Abstract

The hundreds of bacterial genome sequences available together with advances in bioinformatics and the development of new experimental proteomic tools are revolutionizing the vaccinology field. The merge of stringent in silico criteria and different experimental approaches is allowing a more targeted strategy to obtain a restricted and prioritized list of potential antigens for testing in immunogenicity assays, reducing the time and the cost of novel protein vaccine formulations.

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