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. 2010 May;21(5):583-7.
doi: 10.1007/s00192-009-1078-4. Epub 2010 Jan 12.

Urinary incontinence should be added to the manifestation in women with Marfan syndrome

Symphorosa S C Chan  1 , David K H Chan, Selina M W Pang, Stephen T S Lam, Terence T H Lao, Kwong-Wai Choy
Affiliations

Urinary incontinence should be added to the manifestation in women with Marfan syndrome

Symphorosa S C Chan et al. Int Urogynecol J. 2010 May.

Abstract

Introduction and hypothesis: We aimed to compare the incidence of urinary incontinence in women with Marfan syndrome and controls, hypothesizing that connective tissue abnormality could contribute to urinary incontinence.

Methods: A cross-sectional historical cohort study was conducted on 14 premenopausal women with Marfan syndrome and 534 controls using Urogenital Distress Inventory Short Form and Incontinence Impact Questionnaire Short Form.

Results: Marfan subjects had significantly higher incidence of urinary symptoms, stress urinary incontinence (SUI) and urge urinary incontinence (UUI) than controls (P = 0.02, P = 0.03, P = 0.02), despite their lower parity (P = 0.01). Direct logistic regression analysis indicated that Marfan syndrome, parity and age were associated with SUI; while Marfan syndrome was the only significant predictor of UUI.

Conclusions: Premenopausal women with Marfan syndrome had a higher incidence of reported urinary symptoms. Urinary incontinence should be added to the list of clinical manifestations in women with Marfan syndrome.

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