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Review
. 2009 Dec;37(12):875-81.

Role of the transcription factor NFIC in odontoblast gene expression

Mi Young Kim  1 , Julia Reyna, Li-Sha Chen, Maggie Zeichner-David
Affiliations
  • PMID: 20066876
Review

Role of the transcription factor NFIC in odontoblast gene expression

Mi Young Kim et al. J Calif Dent Assoc. 2009 Dec.

Abstract

The transcription factor NFI-C is essential for root development. Mice lacking NFI-C develop abnormal roots and lose their teeth, resembling radicular dentin dysplasia I in humans. The purpose of this study was to understand the role of NFI-C in dentinogenesis. The authors found statistically significant increases in the expression of several mRNAs in cells lacking NFI-C, suggesting that these molecules might interfere with odontoblast cell migration and differentiation, and consequently with root development.

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