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Review
. 2010 May 12;110(5):2921-59.
doi: 10.1021/cr900232t.

Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics

Aaron Joseph L Villaraza  1 , Ambika Bumb, Martin W Brechbiel
Affiliations
Review

Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics

Aaron Joseph L Villaraza et al. Chem Rev. .
No abstract available

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Figures

Figure 1
Figure 1
Relaxation coordination spheres of water: inner-sphere, secondary-sphere, and bulk water.
Figure 2
Figure 2
Commercially available Gd3+ chelate MR agents.
Figure 3
Figure 3
HOPO- and HOIQO-based chelating agents.
Figure 4
Figure 4
Synthesis of G0 Am-, EDA-, DAB- and CYS-core dendrimers.
Figure 5
Figure 5
BFCAs conjugated to dendrimers.
Figure 6
Figure 6
Gd3+ chelate at barycenter of dendrimer.
Figure 7
Figure 7
DTPA- and DOTA-conjugated polylysine (PL), polyethylene glycol (PEG), and mixed PL-PEG species.
Figure 8
Figure 8
Examples of DTPA-copolymers of α,ω–diamines.
Figure 9
Figure 9
MRamp polymerization of paramagentic chelates.
Figure 10
Figure 10
Paramagnetic polymer with biodegradable spacer.
Figure 11
Figure 11
Ligands used for albumin-affinity MR agents.
Figure 12
Figure 12
(A) Cross-linked and (B) amide-linked DTPA-dextran.
Figure 13
Figure 13
Glycodendrimers.
Figure 14
Figure 14
Schematic representations of (A) ensome, (B) memsome, (C) micelle, (D) combined ensome-memsome, and (E) shrunken lipoCEST agent.
Figure 15
Figure 15
DTPA-derivatives (A) stearylamide, (B) stearylester and (C) phosphatidylethanolamine.
Figure 16
Figure 16
Labeling strategies of viral particles: (A) direct encapsulation, (B) conjugation via external lysines, (C) “click” chemistry, (D) functionalization of external lysines, (E) functionalization of internal tyrosines.
Figure 17
Figure 17
(A) Crystalline structure of magnetite. (B) Ferrimagnetic alignment observed from [1,1,1] plane.
Figure 18
Figure 18
(A) Weiss domains in a large magnetite crystal in comparison to a typical SPIO agent. (B) The magnetic alignment of SPIO particles in the absence and presence of an external magnetic field.
Figure 19
Figure 19
The effects of Néel and Brownian relaxation in relation to magnetite crystal radius (according to Rosensweig403).
Figure 20
Figure 20
(A) Néel and Brownian components of electronic relaxation, and (B) effects of Neel and Curie spin relaxation on proton nuclear relaxation.
Figure 21
Figure 21
Manganese chelates.
See this image and copyright information in PMC

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