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NetPath: a public resource of curated signal transduction pathways

Kumaran Kandasamy et al. Genome Biol. .

Abstract

We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.

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Figures

Figure 1
Figure 1
The NetPath homepage. The search function allows users to query the database with multiple options, including gene symbol, protein name, accession number and name of the pathway. The browse option links directly to a page listing all available pathways.
Figure 2
Figure 2
The IL-2 pathway page in NetPath. Hyperlinks to pathway-specific information, such as reactions, transcriptionally regulated genes, molecular associations, and catalysis events, are listed. There is also an option to download pathway information in various data exchange formats from this page.
See this image and copyright information in PMC

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