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. 2010 Apr;33(4):923-5.
doi: 10.2337/dc09-1692. Epub 2010 Jan 12.

Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome

Hanne L Gulseth  1 , Ingrid M F Gjelstad, Audrey C Tierney, Julie A Lovegrove, Catherine Defoort, Ellen E Blaak, Jose Lopez-Miranda, Beata Kiec-Wilk, Ulf Risérus, Helen M Roche, Christian A Drevon, Kåre I Birkeland
Affiliations

Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome

Hanne L Gulseth et al. Diabetes Care. 2010 Apr.

Erratum in

  • Diabetes Care. 2010 Dec;33(12):2725. Ris, Ulférus [corrected to Risérus, Ulf]

Abstract

Objective: To investigate the relation between serum concentration of 25-hydroxyvitamin D [25(OH)D] and insulin action and secretion.

Research design and methods: In a cross-sectional study of 446 Pan-European subjects with the metabolic syndrome, insulin action and secretion were assessed by homeostasis model assessment (HOMA) indexes and intravenous glucose tolerance test to calculate acute insulin response, insulin sensitivity, and disposition index. Serum 25(OH)D was measured by high-performance liquid chromatography/mass spectrometry.

Results: The 25(OH)D(3) concentration was 57.1 +/- 26.0 nmol/l (mean +/- SD), and only 20% of the subjects had 25(OH)D(3) levels > or =75 nmol/l. In multiple linear analyses, 25(OH)D(3) concentrations were not associated with parameters of insulin action or secretion after adjustment for BMI and other covariates.

Conclusions: In a large sample of subjects with the metabolic syndrome, serum concentrations of 25(OH)D(3) did not predict insulin action or secretion. Clear evidence that D vitamin status directly influences insulin secretion or action is still lacking.

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