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Comment
. 2010 Jan 15;16(2):371-2.
doi: 10.1158/1078-0432.CCR-09-2936. Epub 2010 Jan 12.

Individualizing dosing of irinotecan

Mark J Ratain  1 , Federico Innocenti
Affiliations
Comment

Individualizing dosing of irinotecan

Mark J Ratain et al. Clin Cancer Res. .

Abstract

Individualized drug dosing is a longstanding goal of clinical pharmacologists. Given the narrow therapeutic index of most anticancer agents, it is plausible that this approach would be of particular value in oncology. Irinotecan is an interesting agent for individualized dosing, given its complex metabolism and increasing knowledge of its pharmacokinetics predictors.

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