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. 2010 Jan 13;303(2):137-43.
doi: 10.1001/jama.2009.1987.

Funding of US biomedical research, 2003-2008

E Ray Dorsey  1 , Jason de Roulet, Joel P Thompson, Jason I Reminick, Ashley Thai, Zachary White-Stellato, Christopher A Beck, Benjamin P George, Hamilton Moses 3rd
Affiliations

Funding of US biomedical research, 2003-2008

E Ray Dorsey et al. JAMA. .

Abstract

Context: With the exception of the American Recovery and Reinvestment Act, funding support for biomedical research in the United States has slowed after a decade of doubling. However, the extent and scope of slowing are largely unknown.

Objective: To quantify funding of biomedical research in the United States from 2003 to 2008.

Design: Publicly available data were used to quantify funding from government (federal, state, and local), private, and industry sources. Regression models were used to compare financial trends between 1994-2003 and 2003-2007. The numbers of new drug and device approvals by the US Food and Drug Administration over the same period were also evaluated.

Main outcome measures: Funding and growth rates by source; numbers of US Food and Drug Administration approvals.

Results: Biomedical research funding increased from $75.5 billion in 2003 to $101.1 billion in 2007. In 2008, funding from the National Institutes of Health and industry totaled $88.8 billion. In 2007, funding from these sources, adjusted for inflation, was $90.2 billion. Adjusted for inflation, funding from 2003 to 2007 increased by 14%, for a compound annual growth rate of 3.4%. By comparison, funding from 1994 to 2003 increased at an annual rate of 7.8% (P < .001). In 2007, industry (58%) was the largest funder, followed by the federal government (33%). Modest increase in funding was not accompanied by an increase in approvals for drugs or devices. In 2007, the United States spent an estimated 4.5% of its total health expenditures on biomedical research and 0.1% on health services research.

Conclusion: After a decade of doubling, the rate of increase in biomedical research funding slowed from 2003 to 2007, and after adjustment for inflation, the absolute level of funding from the National Institutes of Health and industry appears to have decreased by 2% in 2008.

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Conflict of interest statement

Conflicts of Interest: Potential conflicts of interest are indicated under financial disclosures. The authors report no additional conflicts of interest.

Figures

Figure 1
Figure 1
Funding for Biomedical Reserach by Source, 2003 – 2007
Figure 2
Figure 2
Stock Market Performance of Publicly Traded Life Science and Health Care Companies, 2003 – 2009* *Total return is calculated from January 2, 2003 to November 23, 2009 by the difference in index price from the base price (January 2, 2003) as a percentage of the base price.
See this image and copyright information in PMC

Comment in

References

    1. Moses H, III, Dorsey ER, Matheson DH, Thier SO. Financial Anatomy of Biomedical Research. JAMA. 2005;294:1333–1342. - PubMed
    1. Biomedical Research and Development Price Index (BRDPI) Bethesda, Md: Office of Science and Policy Planning; 2009. [Accessed April 13, 2009]. Available at: http://officeofbudget.od.nih.gov/gbiPriceIndexes.html.
    1. BRDPI: FY 2008 Update and Projections for FY 2009–2014. National Institute of Health, Office of Budget; [Accessed November 23, 2009.]. Available at: http://officeofbudget.od.nih.gov/pdfs/FY09/BRDPI_Proj_Feb_2009_final.pdf.
    1. National Science Foundation, Division of Science Resource Statistics. [Accessed April 13, 2009.];Federal Funds for Research and Development: Fiscal Years 2005–07. Publication No. 09–300. Available at: http://www.nsf.gov/statistics/nsf09300/pdf/nsf09300.pdf.
    1. Funding: Glossary & Acronym List. US Department of Health & Human Services; [Accessed November 23, 2009.]. Available at: http://grants.nih.gov/Grants/glossary.htm.

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