Raxibacumab
- PMID: 20068396
- PMCID: PMC2791309
- DOI: 10.4161/mabs.1.6.10195
Raxibacumab
Abstract
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen. HGS is currently providing stockpiles of the agent to the US government for use in the prevention and treatment of inhalation anthrax. As of May 2009, the candidate was undergoing review by the US Food and Drug Administration. The availability of bioterrorism countermeasures has become more important since the September 2001 anthrax attacks, and development of raxibacumab is a significant advance in this area.
Similar articles
-
Monoclonal antibody therapies against anthrax.Toxins (Basel). 2011 Aug;3(8):1004-19. doi: 10.3390/toxins3081004. Epub 2011 Aug 15. Toxins (Basel). 2011. PMID: 22069754 Free PMC article. Review.
-
Passive Immunotherapy Protects against Enteric Invasion and Lethal Sepsis in a Murine Model of Gastrointestinal Anthrax.Toxins (Basel). 2015 Sep 29;7(10):3960-76. doi: 10.3390/toxins7103960. Toxins (Basel). 2015. PMID: 26426050 Free PMC article.
-
Bacillus anthracis protective antigen kinetics in inhalation spore-challenged untreated or levofloxacin/ raxibacumab-treated New Zealand white rabbits.Toxins (Basel). 2013 Jan 14;5(1):120-38. doi: 10.3390/toxins5010120. Toxins (Basel). 2013. PMID: 23344456 Free PMC article.
-
Raxibacumab for inhalational anthrax: an effective specific therapeutic approach?Expert Opin Investig Drugs. 2010 Jul;19(7):909-11. doi: 10.1517/13543784.2010.489547. Expert Opin Investig Drugs. 2010. PMID: 20450444
-
Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax.Future Microbiol. 2009 Feb;4(1):35-43. doi: 10.2217/17460913.4.1.35. Future Microbiol. 2009. PMID: 19207098 Free PMC article. Review.
Cited by
-
Recent Advances in Monoclonal Antibody-Based Approaches in the Management of Bacterial Sepsis.Biomedicines. 2023 Mar 2;11(3):765. doi: 10.3390/biomedicines11030765. Biomedicines. 2023. PMID: 36979744 Free PMC article. Review.
-
Phage Display Derived Monoclonal Antibodies: From Bench to Bedside.Front Immunol. 2020 Aug 28;11:1986. doi: 10.3389/fimmu.2020.01986. eCollection 2020. Front Immunol. 2020. PMID: 32983137 Free PMC article. Review.
-
Efficacy of ANTHRASIL (Anthrax Immune Globulin Intravenous (Human)) in rabbit and nonhuman primate models of inhalational anthrax: Data supporting approval under animal rule.PLoS One. 2023 Mar 17;18(3):e0283164. doi: 10.1371/journal.pone.0283164. eCollection 2023. PLoS One. 2023. PMID: 36930692 Free PMC article. Clinical Trial.
-
Evolution of phage display libraries for therapeutic antibody discovery.MAbs. 2023 Jan-Dec;15(1):2213793. doi: 10.1080/19420862.2023.2213793. MAbs. 2023. PMID: 37222232 Free PMC article. Review.
-
Application of recombinant antibodies for treatment of Clostridioides difficile infection: Current status and future perspective.Front Immunol. 2022 Aug 23;13:972930. doi: 10.3389/fimmu.2022.972930. eCollection 2022. Front Immunol. 2022. PMID: 36081500 Free PMC article. Review.
References
-
- Inglesby TV, O'Toole T, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, et al. Anthrax as a biological weapon, 2002: updated recommendations for management. JAMA. 2002;287:2236–2252. - PubMed
-
- Zmuda JF, Zhang L, Sosnovtseva S, Bukreyeva N, Beebe L, Hunt R, et al. Detection of host-derived neutralizing antibodies against anthrax protective antigen (PA) in PAmAb-treated monkeys surviving lethal spore challenge: relationship to secondary exposure immunity; American Society of Microbiology Biodefense Meeting; 2004. Abstract 65H. http://www.hgsi.com/images/pdf/asm_monkey_rechallenge.pdf.
-
- Migone TS, Subramanian GM, Zhong J, Healey LM, Corey A, Devalaraja M, et al. Raxibacumab for the treatment of inhalational anthrax. N Engl J Med. 2009;361:135–144. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials