Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jan;21(1):1-12.
doi: 10.1111/j.1600-0501.2009.01826.x.

Evaluation of functional dynamics during osseointegration and regeneration associated with oral implants

Po-Chun Chang  1 , Niklaus P Lang, William V Giannobile
Affiliations
Review

Evaluation of functional dynamics during osseointegration and regeneration associated with oral implants

Po-Chun Chang et al. Clin Oral Implants Res. 2010 Jan.

Abstract

Objectives: The aim of this paper is to review current investigations on functional assessments of osseointegration and assess correlations to the peri-implant structure.

Material and methods: The literature was electronically searched for studies of promoting dental implant osseointegration, functional assessments of implant stability, and finite element (FE) analyses in the field of implant dentistry, and any references regarding biological events during osseointegration were also cited as background information.

Results: Osseointegration involves a cascade of protein and cell apposition, vascular invasion, de novo bone formation and maturation to achieve the primary and secondary dental implant stability. This process may be accelerated by alteration of the implant surface roughness, developing a biomimetric interface, or local delivery of growth-promoting factors. The current available pre-clinical and clinical biomechanical assessments demonstrated a variety of correlations to the peri-implant structural parameters, and functionally integrated peri-implant structure through FE optimization can offer strong correlation to the interfacial biomechanics.

Conclusions: The progression of osseointegration may be accelerated by alteration of the implant interface as well as growth factor applications, and functional integration of peri-implant structure may be feasible to predict the implant function during osseointegration. More research in this field is still needed.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Biomechanical assessments for oral implant osseointegration
(a) tensional test, (b) push-out test, (c) pull-out test, (d) insertional/removal torque test, (e) Periotest, and (e) resonance frequency analysis (RFA).
Figure 2
Figure 2. The in vivo finite element homogenization procedures for functional apparent moduli
(a) The cylinder implant was pushed out (following the direction of the red arrow) from the jaw bone, and (b) the load-displacement relationship was recorded for calculating the interfacial stiffness (dash line, referred to the slope of the curve before the yielding point). (c) The three-dimensional (3-D) peri-implant structure was identified after removing the implant. (d) The finite element model was developed from projecting the peri-implant structure and interfacial information (microscopic model, upper panel) with the suspension boundary condition (pink marks on the peri-implant tissue border). In the optimizing model (lower panels), the peri-implant layer of interest was homogenized (yellow peri-implant regions), and the effective stiffness was calculated from the numerical approximation (to the microscopic model) under the implant loading condition (light blue arrows). Abbreviations: TI: titanium implant; PI: peri-implant tissue; Gr: granulation tissue in peri-implant area; FBAM: functional bone apparent modulus; FCAM: functional composite tissue apparent modulus
See this image and copyright information in PMC

References

    1. Akça K, Cehreli MC, Iplikcioglu H. Evaluation of the mechanical characteristics of the implant-abutment complex of a reduced-diameter morse-taper implant. A nonlinear finite element stress analysis. Clinical Oral Implants Research. 2003;14:444–454. - PubMed
    1. Akça K, Chang TL, Tekdemir I, Fanuscu MI. Biomechanical aspects of initial intraosseous stability and implant design: a quantitative micro-morphometric analysis. Clinical Oral Implants Research. 2006;17:465–472. - PubMed
    1. Alsberg E, Anderson KW, Albeiruti A, Franceschi RT, Mooney DJ. Cell-interactive alginate hydrogels for bone tissue engineering. Journal of Dental Research. 2001;80:2025–2029. - PubMed
    1. Andrades JA, Han B, Becerra J, Sorgente N, Hall FL, Nimni ME. A recombinant human TGF-beta1 fusion protein with collagen-binding domain promotes migration, growth, and differentiation of bone marrow mesenchymal cells. Experimental Cell Research. 1999;250:485–498. - PubMed
    1. Andreykiv A, van Keulen F, Prendergast PJ. Computational mechanobiology to study the effect of surface geometry on peri-implant tissue differentiation. J Biomechanical Engineering. 2008;130:051015. - PubMed

Publication types

Substances