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Review
. 2010 Apr;14(2):184-99.
doi: 10.1016/j.cbpa.2009.11.026. Epub 2010 Jan 12.

Design strategies for the creation of artificial metalloenzymes

Tillmann Heinisch  1 , Thomas R Ward
Affiliations
Review

Design strategies for the creation of artificial metalloenzymes

Tillmann Heinisch et al. Curr Opin Chem Biol. 2010 Apr.

Abstract

In recent years, several complementary strategies have been implemented for the creation and optimization of artificial metalloenzymes. Selected examples outline the pros and cons of five different approaches: catalytic antibodies, computational design, directed evolution, artificial metal-cofactors and DNAzymes.

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