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. 2008 Mar;1(1):7-11.
doi: 10.1007/s12177-008-9002-6. Epub 2008 May 6.

A short-duration dark adaptation protocol for assessment of age-related maculopathy

Gregory R Jackson, John G Edwards

A short-duration dark adaptation protocol for assessment of age-related maculopathy

Gregory R Jackson et al. J Ocul Biol Dis Infor. 2008 Mar.

Abstract

Dark adaptometry may be a useful diagnostic test and clinical trial endpoint for age-related maculopathy (ARM) because impaired night vision is a hallmark of early ARM. A novel dark adaptometer, the AdaptDx, was evaluated for the detection of ARM. The AdaptDx incorporates a 20-minute protocol optimized for the detection of ARM. ARM patients (N = 17) exhibited substantial dark adaptation impairment compared with normal adults (N = 17). The diagnostic sensitivity was 88% and the specificity was 100%. The diagnostic test characteristics of the AdaptDx are similar to previously reported studies using 60- to 120-minute protocols.

Keywords: Age-related macular degeneration; Clinical trial endpoint; Dark adaptation; Diagnostic; Human; Macular degeneration.

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Figures

Fig. 1
Fig. 1
The patient’s view of the AdaptDx. The bleaching light (not shown) is presented through an aperture co-localized with the stimulus light
Fig. 2
Fig. 2
Representative dark adaptation curves of a normal adult (closed circles), early ARM patient (open triangles), and intermediate ARM patient (open circles)
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