[Antimicrobial susceptibility of organisms infecting the urinary tract in northern Israel]

Abstract

Urinary tract infections (UTI), especially in women, are very frequent and require antimicrobial treatment. The choice of drug depends on the susceptibility of the infecting organism. In many cases treatment is begun before the identity and susceptibility of the organism/s cultured are known. Knowledge of the profile of the infecting organisms and their drug susceptibility can improve the treatment of community-acquired UTI. We recorded the distribution and susceptibility of 50,699 positive UTI cultures, during the years 1986-7, in 2 community laboratories in northern Israel serving a population of about 830,000. The sensitivity of organisms to ampicillin was only 32 in the Haifa region and 42 in the Afula region and, respectively, to cotrimoxazole 51 and 76, to cephalexin 60 and 77, to nitrofurantoin 83 and 89, and to nalidixic acid 80 and 92. The differences between the regions were statistically significant. As a result of this study, we suggest that ampicillin should not be used empirically in UTI in these these 2 regions, nor cotrimoxazole in the Haifa region. All women with uncomplicated UTI should be treated with nitrofurantoin or nalidixic acid, provided they are not sensitive to these drugs and tolerate them well. The use of new drugs such as the quinolones and amoxicillin/clavulanic acid must be controlled and monitored to avoid rapid development of resistant strains.