doi: 10.1093/jnci/59.6.1645.
Malignant tumors in rats fed nafenopin, a hepatic peroxisome proliferator
- PMID: 200757
- DOI: 10.1093/jnci/59.6.1645
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Malignant tumors in rats fed nafenopin, a hepatic peroxisome proliferator
J Natl Cancer Inst.
1977 Dec.
Abstract
Nafenopin (2-methyl-2-[P-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy] propionic acid; Su-13,437), a potent hypolipidemic hepatic peroxisome proliferator, was fed to male F344 rats at a dietary concentration of o.1% until the end of the experiment at 25 months. Between 18 and 25 months, 12 of 15 rats (80%) developed tumors. Approximately 73% (11/15) developed hepatocellular carcinomas, and 10% (3/15) developed pancreatic acinar cell tumors, including 1 metastasizing carcinoma. The hepatocellular carcinomas as well as the acinar cell carcinoma of the pancreas were transplantable successfully through 6 generations.
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