Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2010 Jan;89(1):1-17.
doi: 10.1097/MD.0b013e3181cba0a3.

Takayasu arteritis in France: a single-center retrospective study of 82 cases comparing white, North African, and black patients

Laurent Arnaud  1 , Julien Haroche, Nicolas Limal, Dan Toledano, Laetitia Gambotti, Nathalie Costedoat Chalumeau, Du Le Thi Huong Boutin, Patrice Cacoub, Philippe Cluzel, Fabien Koskas, Edouard Kieffer, Jean-Charles Piette, Zahir Amoura
Affiliations
Free article
Comparative Study

Takayasu arteritis in France: a single-center retrospective study of 82 cases comparing white, North African, and black patients

Laurent Arnaud et al. Medicine (Baltimore). 2010 Jan.
Free article

Abstract

We conducted a single-center retrospective study to compare the characteristics of Takayasu arteritis (TA) among white, North African, and black patients in a French tertiary care center (Hospital Pitié-Salpêtrière, Paris). Eighty-two patients were studied (82.9% female) during a median follow-up of 5.1 years (range, 1 mo to 30 yr). Among these 82 patients, 39 (47.6%) were white, 20 (24.4%) were North African, and 20 (24.4%) were black patients. Median age at diagnosis was 39.3 years (range, 14-70 yr) in white patients vs. 28.4 years (range, 12-54 yr) in North African (p = 0.02), and 28.0 years (range, 13-60 yr) in black patients (p = 0.08). Patients aged >40 years at TA onset were more frequently white than non-white (40.0% vs. 18.6%, p = 0.03). North African patients had more frequent occurrence of ischemic stroke (p = 0.03) and poorer survival (p = 0.01) than white patients. Type V of the Hata classification was the most frequent type among white (38.5%), North African (65.0%), and black patients (40.0%). Corticosteroids were used in 96.1% of patients. Fifty-three percent of white and North African patients, and 44% of black patients required a second line of immunosuppressive treatment (p = 0.60). Vascular surgical procedures were respectively performed in 46.1%, 50.0%, and 55.0% of white, North African, and black patients, p = 0.81. The 5-year and 10-year survival rates were 100% and 95.0%, respectively, in white patients; 67.4% at both 5 years and 10 years in North African patients; and 100% at both 5 years and 10 years in black patients. This study is one of the first direct comparisons of TA profiles among patients of distinct ethnic backgrounds. Our data support the idea that late-onset TA or an overlap between TA and large-vessel giant cell arteritis may be observed in white patients. North African patients have a higher occurrence of ischemic stroke and poorer survival than white patients.

PubMed Disclaimer

References

    1. Acar B, Yalcinkaya F, Ozturk B, Yuksel S, Ozcakar ZB, Fitoz S, Buyukcelik M, Noyan A, Sanlidilek U, Ekim M. Seronegative spondyloarthropathy associated with Takayasu's arteritis in a child. Clin Exp Rheumatol. 2005;23:278-279.
    1. Arend WP, Michel BA, Bloch DA, Hunder GG, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY, Lie JT, Lightfoot RW Jr, et al. The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum. 1990;33:1129-1134.
    1. Arnaud L, Haroche J, Malek Z, Archambaud F, Gambotti L, Grimon G, Kas A, Costedoat-Chalumeau N, Cacoub P, Toledano D, Cluzel P, Piette JC, Amoura Z. Is (18)F-fluorodeoxyglucose positron emission tomography scanning a reliable way to assess disease activity in Takayasu arteritis? Arthritis Rheum. 2009;60:1193-1200.
    1. Arnaud L, Kahn JE, Girszyn N, Piette AM, Bletry O. Takayasu's arteritis: an update on physiopathology. Eur J Intern Med. 2006;17:241-246.
    1. Baqir M, Usman MH, Adenwalla HN, Aziz S, Noor F, ul- Islam T, Ahmed M, Hotiana M. Takayasu's arteritis with skin manifestations in a patient with inflammatory bowel disease: coincidence or concurrence? Clin Rheumatol. 2007;26:996-998.

Publication types

LinkOut - more resources