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Comment
. 2006 Nov;4(11):e403.
doi: 10.1371/journal.pbio.0040403. Epub 2006 Oct 24.

Borrowing a DNA repair enzyme to fine-tune antibody specificity

Liza Gross
Comment

Borrowing a DNA repair enzyme to fine-tune antibody specificity

Liza Gross. PLoS Biol. 2006 Nov.
No abstract available

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The authors show that vertebrates exploit the PCNA-ubiquitin pathway—a DNA repair pathway—for immunoglobulin hypermutation, most likely through the recruitment of error-prone DNA polymerases.
See this image and copyright information in PMC

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